EXHIBIT 4.2 AMENDMENT NO. 1 TO RIGHTS AGREEMENT THIS AMENDMENT NO. 1 (this "Amendment"), dated as of November 4, 2002, to the Rights Agreement, dated as of May 10, 2001 (the "Rights Agreement"), between Applied Molecular Evolution, Inc., a Delaware...Rights Agreement • November 5th, 2002 • Applied Molecular Evolution Inc • Services-commercial physical & biological research • Delaware
