0000936392-06-000271 Sample Contracts

ANADYS PHARMCEUTICALS, INC., Issuer AND U.S. BANK NATIONAL ASSOCIATION, Trustee INDENTURE Dated as of March 24, 2006 Senior Debt Securities
Indenture • March 27th, 2006 • Anadys Pharmaceuticals Inc • Pharmaceutical preparations • New York

Indenture, dated as of March 24, 2006, among Anadys Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and U.S. Bank National Association, as trustee (the “Trustee”):

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ANADYS PHARMACEUTICALS, INC. and , As Warrant Agent FORM OF COMMON STOCK WARRANT AGREEMENT Dated As Of
Warrant Agreement • March 27th, 2006 • Anadys Pharmaceuticals Inc • Pharmaceutical preparations • New York

Common Stock Warrant Agreement, dated as of between Anadys Pharmaceuticals, Inc., a Delaware corporation (the “Company") and , a [corporation] [national banking association] organized and existing under the laws of and having a corporate trust office in , as warrant agent (the “Warrant Agent").

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ANADYS PHARMACEUTICALS, INC. and , As Warrant Agent FORM OF PREFERRED STOCK WARRANT AGREEMENT Dated As Of
Warrant Agreement • March 27th, 2006 • Anadys Pharmaceuticals Inc • Pharmaceutical preparations • New York

Preferred Stock Warrant Agreement, dated as of between Anadys Pharmaceuticals, Inc., a Delaware corporation (the “Company”) and , a [corporation] [national banking association] organized and existing under the laws of and having a corporate trust office in , as warrant agent (the “Warrant Agent”).

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ANADYS PHARMACEUTICALS, INC. and , As Warrant Agent FORM OF DEBT SECURITIES WARRANT AGREEMENT Dated As Of
Warrant Agreement • March 27th, 2006 • Anadys Pharmaceuticals Inc • Pharmaceutical preparations • New York

Debt Securities Warrant Agreement, dated as of between Anadys Pharmaceuticals, Inc., a Delaware corporation (the “Company”) and , a [corporation] [national banking association] organized and existing under the laws of and having a corporate trust office in , as warrant agent (the “Warrant Agent”).

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ANADYS PHARMACEUTICALS, INC., Issuer AND U.S. BANK NATIONAL ASSOCIATION, Trustee INDENTURE Dated as of March 24, 2006 Subordinated Debt Securities
Indenture • March 27th, 2006 • Anadys Pharmaceuticals Inc • Pharmaceutical preparations • New York

Indenture, dated as of March 24, 2006, among Anadys Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and U.S. Bank National Association, as trustee (the “Trustee”):

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