0000936392-07-000042 Sample Contracts

Re: Extension of Consulting Agreement with Orexigen Therapeutics, Inc. dated December 9, 2005
Consulting Agreement • January 23rd, 2007 • Orexigen Therapeutics, Inc. • Pharmaceutical preparations

We refer to the Consulting Agreement dated as of December 9, 2005 (the “Consulting Agreement”) between Orexigen Therapeutics, Inc. and PharmaDirections, Inc. As you know, the Term of the Consulting Agreement was set to expire on December 9, 2006. Notwithstanding the foregoing, both parties have continued to work under the terms of the Consulting Agreement following this expiration and as such desire to memorialize their mutual intent to extend the Term until December 31, 2007. Capitalized terms used herein and not otherwise defined herein shall have the meanings set forth in the Consulting Agreement.

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Contract
Consulting Agreement • January 23rd, 2007 • Orexigen Therapeutics, Inc. • Pharmaceutical preparations • North Carolina

THIS CONSULTING AGREEMENT (the “Agreement”) is made and entered into as of 12/9/2005, by and between Orexigen Therapeutics, located at 12481 High Bluff Drive, San Diego, CA 92130 (“Company”) and PharmaDirections, Inc., a North Carolina corporation, located at 5001 Weston Parkway, Suite 103, Cary, NC 27513 (“Consultant”).

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