0000936392-07-000246 Sample Contracts

CHANGE IN CONTROL SEVERANCE AGREEMENT
Change in Control Severance Agreement • March 30th, 2007 • SGX Pharmaceuticals, Inc. • Pharmaceutical preparations • California

This Change in Control Severance Agreement (this “Agreement”) is entered into as of December 18, 2006 (the “Effective Date”), by and between Annette North (the “Executive”) and SGX Pharmaceuticals, Inc., a Delaware corporation (the “Company”).

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FIRST AMENDMENT TO THE DRUG DISCOVERY AGREEMENT
Drug Discovery Agreement • March 30th, 2007 • SGX Pharmaceuticals, Inc. • Pharmaceutical preparations

This First Amendment is entered into by and between SGX Pharmaceuticals, Inc., (formerly known as Structural GenomiX, Inc.) (“SGX”) and Cystic Fibrosis Foundation Therapeutics, Inc. (“CFFT”) and is effective as of March 1, 2007 (“Amendment Effective Date”). Collectively, SGX and CFFT are referred to hereinafter as the “Parties”.

FOURTH AMENDMENT TO LEASE AGREEMENT
Lease Agreement • March 30th, 2007 • SGX Pharmaceuticals, Inc. • Pharmaceutical preparations

THIS FOURTH AMENDMENT TO LEASE AGREEMENT (this “Fourth Amendment”) is made as of March 28, 2007, by and between ARE-10505 ROSELLE STREET, LLC, a Delaware limited liability company (“Landlord”), and SGX PHARMACEUTICALS, INC., a Delaware corporation, formerly known as Structural Genomix, Inc. (“Tenant”).

FIFTH AMENDMENT TO AGREEMENT
Collaboration and License Agreement • March 30th, 2007 • SGX Pharmaceuticals, Inc. • Pharmaceutical preparations

This Amendment to Agreement (the “Amendment”) is made and entered into effective as of March 1, 2007 (the “Amendment Effective Date”), by and between SGX Pharmaceuticals, Inc. (formerly known as Structural GenomiX, Inc.), a corporation organized and existing under the laws of the State of Delaware and having its principal place of business located at 10505 Roselle Street, San Diego, CA 92121 (“SGX”) and Eli Lilly and Company., a corporation organized and existing under the laws of the state of Indiana and having its principal place of business at Lilly Corporate Center, Indianapolis, Indiana 46285, (“Lilly”). Lilly and SGX may be referred to herein as a “Party” or, collectively, as “Parties”.

SECOND AMENDMENT TO LEASE AGREEMENT
Lease Agreement • March 30th, 2007 • SGX Pharmaceuticals, Inc. • Pharmaceutical preparations

THIS SECOND AMENDMENT TO LEASE AGREEMENT (this “Second Amendment”) is made as of March 28, 2007, by and between ARE-3770 TANSY STREET, LLC, a Delaware limited liability company (“Landlord”), and SGX PHARMACEUTICALS, INC., a Delaware corporation, formerly known as Structural Genomix, Inc. (“Tenant”).

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