0000936392-07-000842 Sample Contracts

SECOND AMENDMENT TO CREDIT AND SECURITY AGREEMENT
Credit and Security Agreement • November 8th, 2007 • Orexigen Therapeutics, Inc. • Pharmaceutical preparations • Illinois

This Second Amendment to Credit and Security Agreement (“Amendment”) is made as of this 6th day of November, 2007, by and among OREXIGEN THERAPEUTICS, INC., a Delaware corporation (the “Borrower”), those financial institutions listed on the signature pages hereto as the “Lenders” party to the Credit Agreement referenced below and MERRILL LYNCH CAPITAL, a division of Merrill Lynch Business Financial Services Inc., as “Administrative Agent” under the Credit Agreement referenced below.

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