0000936392-08-000710 Sample Contracts

AMENDMENT TO MANUFACTURING AGREEMENT
Manufacturing Agreement • November 7th, 2008 • Nuvasive Inc • Surgical & medical instruments & apparatus

THIS AMENDMENT TO MANUFACTURING AGREEMENT (“Amendment”) is made and entered into as of September 30, 2008 (the “Effective Date”), by and between Osiris Therapeutics, Inc., a Delaware corporation (“Osiris”), and NuVasive, Inc., a Delaware corporation (“NuVasive”):

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AMENDMENT TO ASSET PURCHASE AGREEMENT
Asset Purchase Agreement • November 7th, 2008 • Nuvasive Inc • Surgical & medical instruments & apparatus • Delaware

This AMENDMENT TO ASSET PURCHASE AGREEMENT (this “Amendment”) dated as of September 30, 2008, is by and between Osiris Therapeutics, Inc., a Delaware corporation (“Seller”), and NuVasive, Inc., a Delaware corporation (“Purchaser”). Capitalized terms used herein and not otherwise defined shall have the meaning given them in the Asset Purchase Agreement, dated May 8, 2008, between Seller and Purchaser (the “Agreement”). Seller and Purchaser shall each be referred to herein as a “Party” and collectively as the “Parties.”

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