1 EXHIBIT 10.5 ISIS PHARMACEUTICALS, INC. REGISTRATION RIGHTS AGREEMENT THIS REGISTRATION RIGHTS AGREEMENT (the "Agreement") is made as of April 20, 1999 by and among ISIS PHARMACEUTICALS, INC., a Delaware corporation (the "Company"), and ELAN...Registration Rights Agreement • May 3rd, 1999 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • Delaware
1 EXHIBIT 10.2 SECURITIES PURCHASE AGREEMENT SECURITIES PURCHASE AGREEMENT (this "Agreement"), dated as of April 20, 1999, between ISIS PHARMACEUTICALS, INC., a Delaware corporation (the "Company"), and ELAN INTERNATIONAL SERVICES, LTD., a Bermuda...Securities Purchase Agreement • May 3rd, 1999 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • Delaware
ORASENSE LTDLicense Agreement • May 3rd, 1999 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York
ORASENSE LTD. REGISTRATION RIGHTS AGREEMENTRegistration Rights Agreement • May 3rd, 1999 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York
1 EXHIBIT 10.4 THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT UNDER ANY CIRCUMSTANCES BE SOLD, TRANSFERRED OR OTHERWISE DISPOSED OF WITHOUT...Isis Pharmaceuticals Inc • May 3rd, 1999 • Pharmaceutical preparations • Delaware
TEXT OMITTED AND FILED SEPARATELY CONFIDENTIAL TREATMENT REQUESTED UNDER 17 C.F.R. SECTIONS 200.80(B)(4), 200.83 AND 240.24B-2 SUBSCRIPTION, JOINT DEVELOPMENT AND OPERATING AGREEMENT ELAN CORPORATION, PLC ELAN INTERNATIONAL SERVICES, LTD.Development and Operating Agreement • May 3rd, 1999 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York
