0000939767-20-000035 Sample Contracts

FIRST AMENDMENT TO LEASE AGREEMENT
Lease Agreement • February 25th, 2020 • Exelixis, Inc. • Services-commercial physical & biological research

THIS FIRST AMENDMENT TO LEASE AGREEMENT (this “Amendment”) is made and entered into on January 16, 2020 (the “Execution Date”) by and between ALAMEDA BTS EDP, LLC, a California limited liability company (“Landlord”), and EXELIXIS, INC., a Delaware corporation (“Tenant”).

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AMENDMENT No. 3
Clinical Trial Collaboration Agreement • February 25th, 2020 • Exelixis, Inc. • Services-commercial physical & biological research

This Amendment No. 3 (this “Amendment No. 3”) is entered into as of November 22, 2019 (the “Amendment No. 3 Date”), and is made and entered into by and between Exelixis, Inc., a Delaware corporation, located at 1851 Harbor Bay Parkway, Alameda, CA 94502 (“Exelixis”) and Bristol-Myers Squibb Company, a Delaware corporation, headquartered at 345 Park Avenue, New York, New York 10154 (“BMS”)

FIFTH AMENDMENT TO LEASE AGREEMENT
Lease Agreement • February 25th, 2020 • Exelixis, Inc. • Services-commercial physical & biological research

THIS FIFTH AMENDMENT TO LEASE AGREEMENT (this “Amendment”) is made and entered into on January 16, 2020 (the "Execution Date") by and between ALAMEDA WATERFRONT EDP, LLC, a California limited liability company (“Landlord”), and EXELIXIS, INC., a Delaware corporation (“Tenant”).

JOINT CLINICAL RESEARCH AGREEMENT
Joint Clinical Research Agreement • February 25th, 2020 • Exelixis, Inc. • Services-commercial physical & biological research • California

This JOINT CLINICAL RESEARCH AGREEMENT (the “Agreement”) is made and entered into effective as December 18, 2019 (the “Effective Date”) by and between Exelixis, Inc., a Delaware corporation having an address at 1851 Harbor Bay Parkway, Alameda, CA 94502 (“Exelixis”) and F. Hoffmann-La Roche Ltd, a Swiss corporation having an address at Grenzacherstrasse 124, CH 4070 Basel, Switzerland (“Roche”). Exelixis and Roche may be referred to herein individually as a “Party,” or collectively as the “Parties”.

SUPPLEMENT TO THE JOINT CLINICAL RESEARCH AGREEMENT
Joint Clinical Research Agreement • February 25th, 2020 • Exelixis, Inc. • Services-commercial physical & biological research • California

This SUPPLEMENT TO THE JOINT CLINICAL RESEARCH AGREEMENT (the “Supplement”) is made and entered into effective as of December 18, 2019 (the “Effective Date”) by and among Exelixis, Inc. a Delaware corporation, located at 1851 Harbor Bay Parkway, Alameda, CA 94501, (“Exelixis”), F. Hoffmann-La Roche Ltd, a Swiss corporation having an address at Grenzacherstrasse 124, CH 4070 Basel, Switzerland (“Roche”), and Ipsen Pharma SAS, a French Corporation having an address at 65 Quai Georges Gorse, 92100 Boulogne-Billancourt, France (“Ipsen”). The terms in this Supplement with initial letters capitalized, whether used in the singular or the plural, shall have the meaning set forth herein, or if not defined herein, as set forth in the Agreement.

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