0000945234-06-000115 Sample Contracts

FORM OF SUBSCRIPTION AGREEMENT FOR SPECIAL WARRANTS
Cardiome Pharma Corp • February 17th, 2006 • Pharmaceutical preparations • British Columbia

The undersigned subscriber (the “Subscriber”) hereby irrevocably subscribes for special warrants (the “Special Warrants”) of Cardiome Pharma Corp. (the “Corporation”) for an aggregate subscription price of $ (the “Subscription Price”), representing a subscription price of $7.2387 per Special Warrant, on the terms and conditions set forth in this Agreement (the “Subscription Agreement”). The Subscription Agreement is being entered into pursuant to a letter agreement (the “Letter Agreement”) dated August 29, 2005 between the Corporation and the Subscriber, among others.

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AMENDMENT NO. 1 TO SUBSCRIPTION AGREEMENT
Subscription Agreement • February 17th, 2006 • Cardiome Pharma Corp • Pharmaceutical preparations

This Amendment No. 1 to the Subscription Agreement (the “Amendment”) is made and entered into as of February 14, 2006 by and between (“Subscriber”) and Cardiome Pharma Corp. (the "Corporation”).

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