0000947871-13-000759 Sample Contracts

RELYPSA, INC. SECOND AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT
Investor Rights Agreement • December 2nd, 2013 • Orbimed Advisors LLC • Pharmaceutical preparations • Delaware

THIS SECOND AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the “Agreement”) is entered into as of the 26th day of July, 2012 (the “Effective Date”), by and among RELYPSA, INC., a Delaware corporation (the “Company”) and the investors listed on EXHIBIT A hereto, referred to hereinafter as the “Investors” and each individually as an “Investor.”

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JOINT FILING AGREEMENT
Joint Filing Agreement • December 2nd, 2013 • Orbimed Advisors LLC • Pharmaceutical preparations

The undersigned hereby agree that the Statement on this Schedule 13D, dated December 2, 2013 (the “Schedule 13D”), with respect to the Common Stock, of Relypsa, Inc. is filed on behalf of each of us pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities and Exchange Act of 1934, as amended, and that this Agreement shall be included as an Exhibit to this Schedule 13D. Each of the undersigned agrees to be responsible for the timely filing of the Schedule 13D, and for the completeness and accuracy of the information concerning itself contained therein. This Agreement may be executed in any number of counterparts, all of which taken together shall constitute one and the same instrument.

FORM OF LOCK-UP LETTER
Lock-Up Agreement • December 2nd, 2013 • Orbimed Advisors LLC • Pharmaceutical preparations
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