0000947871-17-000247 Sample Contracts

LOCK-UP AND NO SHORTING AGREEMENT
Lock-Up and No Shorting Agreement • March 27th, 2017 • Orbimed Advisors LLC • Pharmaceutical preparations • New York

This LOCK-UP AND NO SHORTING AGREEMENT (this “Agreement”) is made as of March __, 2017, by and between the undersigned person or entity (the “Restricted Holder”) and Aerpio Pharmaceuticals, Inc. (formerly known as Zeta Acquisition Corp. II), a Delaware corporation (the “Parent”). Capitalized terms used and not otherwise defined herein shall have the meanings given to such terms in the Merger Agreement (as defined below).

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JOINT FILING AGREEMENT
Joint Filing Agreement • March 27th, 2017 • Orbimed Advisors LLC • Pharmaceutical preparations

The undersigned hereby agree that the Statement on this Schedule 13D, dated March 27, 2017 (the “Schedule 13D”), with respect to the Common Stock, of Aerpio Pharmaceuticals, Inc. is filed on behalf of each of us pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, and that this Agreement shall be included as an Exhibit to this Schedule 13D. Each of the undersigned agrees to be responsible for the timely filing of the Schedule 13D, and for the completeness and accuracy of the information concerning itself contained therein. This Agreement may be executed in any number of counterparts, all of which taken together shall constitute one and the same instrument.

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