0000950103-05-001377 Sample Contracts

COLLABORATION AGREEMENT BY AND AMONG SHIRE LLC SHIRE PHARMACEUTICALS PLC AND NEW RIVER PHARMACEUTICALS INC. DATED AS OF JANUARY 31, 2005
Collaboration Agreement • May 9th, 2005 • Shire Pharmaceuticals Group PLC • Pharmaceutical preparations • New York

THIS COLLABORATION AGREEMENT (the “Agreement”) is dated as of January 31, 2005 (the “Effective Date”) by and among SHIRE LLC, a Kentucky limited liability company having a principal place of business at 9200 Brookfield Court, Florence, Kentucky 41042 (“Shire”), SHIRE PHARMACEUTICALS GROUP PLC, a British public limited company having a principal place of business at Hampshire International Business Park, Chineham, Basingstoke, England RG24 8EP, solely for purposes of the provisions of Section 15.10 of this Agreement, and NEW RIVER PHARMACEUTICALS INC., a Virginia corporation having a principal place of business at 1881 Grove Avenue, Radford, Virginia 24141 (“New River”). Shire and New River are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

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ROW TERRITORY LICENSE AGREEMENT BY AND AMONG SHIRE PHARMACEUTICALS IRELAND LIMITED SHIRE PHARMACEUTICALS PLC AND NEW RIVER PHARMACEUTICALS INC. DATED AS OF MARCH 31, 2005
Row Territory License Agreement • May 9th, 2005 • Shire Pharmaceuticals Group PLC • Pharmaceutical preparations • New York

THIS ROW TERRITORY LICENSE AGREEMENT (the “Agreement”) is dated as of March 31, 2005 by and among SHIRE PHARMACEUTICALS IRELAND LIMITED , an Irish resident company having a principal place of business at 2nd Floor, Unit 1A, Citylink Business Park, Old Naas Road, Dublin 12, Ireland (“Shire”), SHIRE PHARMACEUTICALS GROUP PLC, a British public limited company having a principal place of business at Hampshire International Business Park, Chineham, Basingstoke, England RG24 8EP, solely for purposes of the provisions of Section 14.10 of this Agreement, and NEW RIVER PHARMACEUTICALS INC., a Virginia corporation having a principal place of business at 1881 Grove Avenue, Radford, Virginia 24141 (“New River”). Shire and New River are sometimes referred to herein individually as a “Party” and collectively as the “Parties”.

UNITED STATES COLLABORATION AGREEMENT BY AND AMONG SHIRE LLC SHIRE PHARMACEUTICALS PLC AND NEW RIVER PHARMACEUTICALS INC. DATED AS OF MARCH 31, 2005
United States Collaboration Agreement • May 9th, 2005 • Shire Pharmaceuticals Group PLC • Pharmaceutical preparations • New York

THIS UNITED STATES COLLABORATION AGREEMENT (the “Agreement”) is dated as of March 31, 2005 by and among SHIRE LLC, a Kentucky limited liability company having a principal place of business at 9200 Brookfield Court, Florence, Kentucky 41042 (“Shire”), SHIRE PHARMACEUTICALS GROUP PLC, a British public limited company having a principal place of business at Hampshire International Business Park, Chineham, Basingstoke, England RG24 8EP, solely for purposes of the provisions of Section 15.10 of this Agreement, and NEW RIVER PHARMACEUTICALS INC., a Virginia corporation having a principal place of business at 1881 Grove Avenue, Radford, Virginia 24141 (“New River”). Shire and New River are sometimes referred to herein individually as a “Party” and collectively as the “Parties”.

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