0000950103-05-002388 Sample Contracts

EXCHANGEABLE SHARE SUPPORT AGREEMENT

Exchangeable Share Support Agreement • November 25th, 2005 • Shire PLC • Pharmaceutical preparations

• Contract Type
  Exchangeable Share Support Agreement
• Filed
  November 25th, 2005
• Company
  Shire PLC
• Industry
  Pharmaceutical preparations

WHEREAS, pursuant to a merger agreement (the “Merger Agreement”) dated as of December 10, 2000 by and among Shire Pharmaceuticals Group plc, a company registered in England under registry number 2883758 ("SPG”), ExchangeCo and BioChem Pharma Inc. (now known as Shire BioChem Inc.), a corporation existing under the laws of Canada (“BioChem”), ExchangeCo has issued Exchangeable Shares (the “Exchangeable Shares”) to certain holders of common shares of BioChem pursuant to the plan of arrangement appended to the Merger Agreement;

VOTING AND EXCHANGE TRUST AGREEMENT

Voting and Exchange Trust Agreement • November 25th, 2005 • Shire PLC • Pharmaceutical preparations

• Contract Type
  Voting and Exchange Trust Agreement
• Filed
  November 25th, 2005
• Company
  Shire PLC
• Industry
  Pharmaceutical preparations

WHEREAS pursuant to a merger agreement (the “Merger Agreement”) dated as of December 10, 2000 by and among Shire Pharmaceuticals Group plc, a company registered in England under registry number 2883758 (“SPG”), ExchangeCo and BioChem Pharma Inc. (now known as Shire BioChem Inc.), a corporation existing under the laws of Canada (“ BioChem”), ExchangeCo has issued Exchangeable Shares (the “Exchangeable Shares”) to certain holders of common shares of BioChem pursuant to the plan of arrangement (the “Plan of Arrangement”) appended to the Merger Agreement;