0000950103-05-002388 Sample Contracts

EXCHANGEABLE SHARE SUPPORT AGREEMENT
Exchangeable Share Support Agreement • November 25th, 2005 • Shire PLC • Pharmaceutical preparations

WHEREAS, pursuant to a merger agreement (the “Merger Agreement”) dated as of December 10, 2000 by and among Shire Pharmaceuticals Group plc, a company registered in England under registry number 2883758 ("SPG”), ExchangeCo and BioChem Pharma Inc. (now known as Shire BioChem Inc.), a corporation existing under the laws of Canada (“BioChem”), ExchangeCo has issued Exchangeable Shares (the “Exchangeable Shares”) to certain holders of common shares of BioChem pursuant to the plan of arrangement appended to the Merger Agreement;

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VOTING AND EXCHANGE TRUST AGREEMENT
Voting and Exchange Trust Agreement • November 25th, 2005 • Shire PLC • Pharmaceutical preparations

WHEREAS pursuant to a merger agreement (the “Merger Agreement”) dated as of December 10, 2000 by and among Shire Pharmaceuticals Group plc, a company registered in England under registry number 2883758 (“SPG”), ExchangeCo and BioChem Pharma Inc. (now known as Shire BioChem Inc.), a corporation existing under the laws of Canada (“ BioChem”), ExchangeCo has issued Exchangeable Shares (the “Exchangeable Shares”) to certain holders of common shares of BioChem pursuant to the plan of arrangement (the “Plan of Arrangement”) appended to the Merger Agreement;

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