0000950103-07-001983 Sample Contracts

Dated 8 May 2007
Shire PLC • August 2nd, 2007 • Pharmaceutical preparations

Shire plc and ABN AMRO Bank N.V. and NM Rothschild & Sons Limited (trading together as ABN AMRO Rothschild, an unincorporated equity capital markets joint venture) and Barclays Bank PLC and Citigroup Global Markets Limited and Goldman Sachs International and Morgan Stanley & Co. International plc and Others AMENDING SUBSCRIPTION AGREEMENT U.S.$1,000,000,000 2.75 per cent Convertible Bonds due 2014 (subject to an increase by up to a further U.S.$100,000,000 pursuant to the exercise of an over-allotment option described herein) convertible into ordinary shares of Shire plc

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Dated 2 May 2007
Subscription Agreement • August 2nd, 2007 • Shire PLC • Pharmaceutical preparations

Shire plc and ABN AMRO Bank N.V. and NM Rothschild & Sons Limited (trading together as ABN AMRO Rothschild, an unincorporated equity capital markets joint venture) and Barclays Bank PLC and Citigroup Global Markets Limited and Goldman Sachs International and Morgan Stanley & Co. International plc and Others SUBSCRIPTION AGREEMENT U.S.$1,000,000,000 2.75 per cent Convertible Bonds due 2014 (subject to an increase by up to a further U.S.$100,000,000 pursuant to the exercise of an over-allotment option described herein) convertible into ordinary shares of Shire plc

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