0000950103-09-001040 Sample Contracts

AMENDMENT TO PRODUCT DEVELOPMENT AND LICENSE AGREEMENT
Product Development and License Agreement • May 7th, 2009 • Shire PLC • Pharmaceutical preparations

This Amendment to the Product Development and License Agreement, effective as of February 24, 2009, is by and between Shire LLC, Shire Biopharmaceuticals Holdings (formerly known as Shire plc) (collectively “Shire”) and Duramed Pharmaceuticals, Inc. (“Duramed”). Shire and Duramed are referred to together as the “Parties”.

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