0000950103-19-009212 Sample Contracts

Amendment NO.1 to Agreement and Plan of Merger
Agreement and Plan of Merger • July 8th, 2019 • Roche Holdings Inc

This Amendment NO.1 to Agreement and Plan of Merger (this “Amendment”) is entered into as of July 5, 2019 by and among Roche Holdings, Inc., a Delaware corporation (“Parent”), 022019 Merger Subsidiary, Inc., a Delaware corporation and a wholly owned subsidiary of Parent (“Merger Sub”), and Spark Therapeutics, Inc., a Delaware corporation (the “Company” and, together with Parent and Merger Sub, the “Parties”).

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