Exhibit 4.1 SECOND AMENDED AND RESTATED STOCKHOLDERS AGREEMENT SECOND AMENDED AND RESTATED STOCKHOLDERS AGREEMENT dated as of the 23rd day of December, 1999, by and among ORAPHARMA, INC., a Delaware corporation (the "Company"), and those stockholders...Stockholders Agreement • December 30th, 1999 • Orapharma Inc • New Jersey
RECITALS --------License Agreement • December 30th, 1999 • Orapharma Inc • Minnesota
STOCK PURCHASE AGREEMENT (this "Agreement") dated as of the 23 day of --------- December, 1999, by and among OraPharma, Inc., a Delaware corporation (theStock Purchase Agreement • December 30th, 1999 • Orapharma Inc • New Jersey
Exhibit 4.11 RESTRICTED STOCK AGREEMENT --------------------------Restricted Stock Agreement • December 30th, 1999 • Orapharma Inc • New Jersey
Exhibit 10.7 LICENSE AGREEMENTLicense Agreement • December 30th, 1999 • Orapharma Inc • New York
AGREEMENTAgreement • December 30th, 1999 • Orapharma Inc • New Jersey
AGREEMENT ---------Orapharma Inc • December 30th, 1999 • New Jersey
Exhibit 4.13 RESTRICTED STOCK PURCHASE AGREEMENT -----------------------------------Restricted Stock Purchase Agreement • December 30th, 1999 • Orapharma Inc • New Jersey
Exhibit 4.12 THIS WARRANT AND THE SECURITIES TO BE ISSUED UPON EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE AND MAY NOT BE OFFERED, SOLD, TRANSFERRED, PLEDGED, HYPOTHECATED...Stock Warrant Agreement • December 30th, 1999 • Orapharma Inc • New York
Exhibit 10.5 CHILDREN'S HOSPITAL SPONSORED RESEARCH AGREEMENT THIS AGREEMENT is entered into effective the 31st day of December, 1998 (the "Effective Date") by and between CHILDREN'S HOSPITAL, a charitable corporation duly organized and existing under...S Hospital Sponsored Research Agreement • December 30th, 1999 • Orapharma Inc • Massachusetts
Exhibit 10.8 RESEARCH AND CONSULTING AGREEMENTResearch and Consulting Agreement • December 30th, 1999 • Orapharma Inc • New York
Exhibit 10.6 EXCLUSIVE LICENSE AGREEMENT This Agreement is made and entered into as of December 31, 1998 (the Effective Date), by and between CHILDREN'S MEDICAL CENTER CORPORATION, a charitable corporation duly organized and existing under the laws of...Exclusive License Agreement • December 30th, 1999 • Orapharma Inc • Massachusetts
