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0000950123-03-009070 Sample Contracts

Guilford Pharmaceuticals Inc. $60,000,000 5% Convertible Subordinated Notes Due 2008 REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • August 7th, 2003 • Guilford Pharmaceuticals Inc • Pharmaceutical preparations • New York

Citigroup Global Markets Inc. CIBC World Markerts Corp. As Representatives of the Initial Purchasers c/o Citigroup Global Markets Inc. 388 Greenwich Street New York, New York 10013

INDENTURE between Guilford Pharmaceuticals Inc. and Wachovia Bank, National Association as Trustee 5% Convertible Subordinated Notes due 2008*
Indenture • August 7th, 2003 • Guilford Pharmaceuticals Inc • Pharmaceutical preparations • New York

THIS INDENTURE, dated as of June 17, 2003, is between Guilford Pharmaceuticals Inc., a Delaware corporation (the “Company”), and Wachovia Bank, National Association, a national banking association, as trustee (the “Trustee”). The Company has duly authorized the creation of its 5% Convertible Subordinated Notes due 2008 (the “Convertible Notes”), and to provide therefor the Company and the Trustee have duly authorized the execution and delivery of this Indenture. Each party agrees as follows for the benefit of the other party and for the equal and ratable benefit of the holders from time to time of the Convertible Notes: