0000950123-05-000248 Sample Contracts

SECOND AMENDMENT TO COLLABORATION AGREEMENT
Collaboration Agreement • January 11th, 2005 • Regeneron Pharmaceuticals Inc • Pharmaceutical preparations • New York

This Second Amendment to Collaboration Agreement (this “Second Amendment”) dated as of January 7, 2005 (the “Second Amendment Effective Date”), is by and between Regeneron Pharmaceuticals, Inc., a corporation organized and existing under the laws of the State of New York and having its principal office at 777 Old Saw Mill River Road, Tarrytown, New York 10591 (“Regeneron ”) and Aventis Pharmaceuticals Inc., a corporation organized and existing under the laws of the State of Delaware and having a principal place of business at 200 Crossing Blvd., Bridgewater, New Jersey 08807 (“Aventis”).

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