EXHIBIT 10.10.1 AMENDMENT AND AGREEMENT This Amendment and Agreement (this "Amendment") is made as of the 30th of June, 2005. BETWEEN: REGENERON PHARMACEUTICALS, INC. a New York corporation having its principal office at 777 Old Saw Mill River Road,...Focused Collaboration Agreement • August 8th, 2005 • Regeneron Pharmaceuticals Inc • Pharmaceutical preparations • Delaware
