0000950123-08-004520 Sample Contracts

AGREEMENT AND PLAN OF MERGER among SMITHKLINE BEECHAM CORPORATION, FOUNTAIN ACQUISITION CORPORATION and SIRTRIS PHARMACEUTICALS, INC. Dated as of April 22, 2008

Agreement and Plan of Merger • April 23rd, 2008 • Sirtris Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

• Contract Type
  Agreement and Plan of Merger
• Filed
  April 23rd, 2008
• Company
  Sirtris Pharmaceuticals, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Delaware

AGREEMENT AND PLAN OF MERGER, dated as of April 22, 2008 (this “Agreement”), among SmithKline Beecham Corporation, a Pennsylvania corporation (“Parent”), Fountain Acquisition Corporation, a Delaware corporation and wholly-owned Subsidiary of Parent (“Purchaser”), and Sirtris Pharmaceuticals, Inc., a Delaware corporation (the “Company”).

TENDER AND STOCKHOLDER SUPPORT AGREEMENT

Tender and Stockholder Support Agreement • April 23rd, 2008 • Sirtris Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

• Contract Type
  Tender and Stockholder Support Agreement
• Filed
  April 23rd, 2008
• Company
  Sirtris Pharmaceuticals, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Delaware

This TENDER AND STOCKHOLDER SUPPORT AGREEMENT (this “Agreement”), dated , is by and among SmithKline Beecham Corporation, a Pennsylvania corporation (“Parent”), Fountain Acquisition Corporation, a Delaware corporation and wholly-owned Subsidiary of Parent (“Purchaser”), and certain stockholders of Sirtris Pharmaceuticals, Inc., a Delaware corporation (the “Company”), set forth on Schedule A hereto (each a “Stockholder” and, collectively the “Stockholders”).