0000950123-09-033931 Sample Contracts

ONYX PHARMACEUTICALS, INC. as Issuer AND WELLS FARGO BANK, NATIONAL ASSOCIATION as Trustee First Supplemental Indenture Dated as of August 12, 2009 to Indenture dated as of August 12, 2009 4.00% Convertible Senior Notes due 2016
Indenture • August 12th, 2009 • Onyx Pharmaceuticals Inc • Biological products, (no disgnostic substances) • New York

FIRST SUPPLEMENTAL INDENTURE dated as of August 12, 2009 (“Supplemental Indenture”), to the Indenture dated as of August 12, 2009 (as amended, modified or supplemented from time to time in accordance therewith, the “Base Indenture” and, as amended, modified and supplemented by this Supplemental Indenture, the “Indenture”), by and among ONYX PHARMACEUTICALS, INC., a Delaware corporation (the “Company”) and WELLS FARGO BANK, NATIONAL ASSOCIATION as trustee (the “Trustee”).

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