0000950123-10-043213 Sample Contracts

November 16, 2009 Craig Collard President and CEO Cornerstone Therapeutics Inc. 1255 Crescent Green Drive, Suite 250 Cary, NC 27518 Dear Mr. Collard,
License and Supply Agreement • May 4th, 2010 • Cornerstone Therapeutics Inc • Pharmaceutical preparations

We refer to the License and Supply Agreement dated October 12, 2006 regarding Cefditoren Pivoxil, as amended by Amendment No. 1 dated July 27, 2007 (the “License Agreement”) and the Addendum thereto dated August 14, 2008 (the “Addendum”).

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THIS AMENDMENT NO. 2 is made this 28th day of January, 2010 BETWEEN: RECITALS: OPERATIVE PROVISIONS:
License Agreement • May 4th, 2010 • Cornerstone Therapeutics Inc • Pharmaceutical preparations
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