0000950123-10-043375 Sample Contracts

FIRST AMENDMENT TO THE COLLABORATION AND LICENSE AGREEMENT OF 7 SEPTEMBER 2006
Collaboration and License Agreement • May 4th, 2010 • GTX Inc /De/ • Pharmaceutical preparations

This First Amendment to the Collaboration and License Agreement of 7 September 2006 (the “First Amendment”) is entered into and is effective as of 22 March, 2010 by and between Ipsen Biopharm Limited, a company organized and existing under the laws of England and Wales, with registered offices located at Ash Road, Wrexham Industrial Estate, Wrexham LL13 9UF, United Kingdom (“Ipsen”)1 and GTx, Inc., a Delaware corporation having its principal place of business at 175 Toyota Plaza, 7th Floor, Memphis, Tennessee 38103 (“GTx”), each on behalf of itself and its Affiliates (Ipsen and GTx, collectively, the “Parties” and individually a “Party”).

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