0000950123-10-074020 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • August 6th, 2010 • NxStage Medical, Inc. • Electromedical & electrotherapeutic apparatus • Delaware

This Agreement is made in connection with the Warrant to Purchase Shares of Common Stock dated as of the date hereof, by and between the Company and DaVita (the “Warrant Agreement”).

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NXSTAGE MEDICAL, INC. WARRANT TO PURCHASE SHARES OF COMMON STOCK July 22, 2010
NxStage Medical, Inc. • August 6th, 2010 • Electromedical & electrotherapeutic apparatus • Delaware

THIS CERTIFIES THAT, for value received, DaVita Inc., a Delaware corporation, is entitled to subscribe for and purchase up to a maximum of 5,500,000 shares (subject to vesting pursuant to Section 2 and adjustment pursuant to Section 5 hereof, the “Shares”) of fully paid and nonassessable common stock, par value $0.001 per share (“Common Stock”), of NxStage Medical, Inc., a Delaware corporation (the “Company”), at the price of $14.22 per share (such price and such other price as shall result, from time to time, from the adjustments specified in Section 5 hereof is herein referred to as the “Warrant Price”), subject to the provisions and upon the terms and conditions set forth herein and in the First Amended and Restated National Service Provider Agreement — Chronic Outpatient Therapy dated as of even date herewith, including any exhibit and schedule attached thereto (collectively, the “Chronic Outpatient Therapy Agreement”), by and between the Company and the holder of this Warrant. As

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