0000950123-10-115172 Sample Contracts

Contract
Confidentiality Agreement • December 21st, 2010 • Cypress Bioscience Inc • Biological products, (no disgnostic substances) • California

Jeffrey C. Smith Ramius Value and Opportunity Advisors, LLC Ramius V&O Acquisition LLC 599 Lexington Avenue, 20th Floor New York, New York 10022

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RP Management, LLC 110 East 59th Street Suite 3300 New York, NY. 10022 Confidentiality Agreement Ladies and Gentlemen:
Confidentiality Agreement • December 21st, 2010 • Cypress Bioscience Inc • Biological products, (no disgnostic substances) • California

In connection with the financing of a potential transaction involving Cypress Bioscience, Inc. and its subsidiaries (collectively, the “Company”) and Ramius Value and Opportunity Advisors LLC and Ramius V&O Acquisition LLC (“Ramius”) and/or a possible negotiated transaction between RP Management, LLC (the “Recipient”) and the Company, the Recipient has requested access to certain non-public information regarding the Company. This letter agreement sets forth the Recipient’s obligations regarding the use and disclosure of such information and regarding various related matters.

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