0000950123-11-015737 Sample Contracts

AMENDED AND RESTATED LICENSE AND COLLABORATION AGREEMENT by and between TEKMIRA PHARMACEUTICALS CORPORATION and ALNYLAM PHARMACEUTICALS, INC.
License and Collaboration Agreement • February 18th, 2011 • Alnylam Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

This AMENDED AND RESTATED LICENSE AND COLLABORATION AGREEMENT, effective as of May 30, 2008, is made by and between Tekmira Pharmaceuticals Corporation (as successor in interest to INEX Pharmaceuticals Corporation (“INEX”)), a corporation organized and existing under the laws of British Columbia, Canada (“Tekmira”), and Alnylam Pharmaceuticals, Inc., a corporation organized and existing under the laws of Delaware, U.S.A (“Alnylam”).

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ALNYLAM PHARMACEUTICALS, INC. Form of Restricted Stock Agreement
Restricted Stock Agreement • February 18th, 2011 • Alnylam Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

Alnylam Pharmaceuticals, Inc. (the “Company”) has selected you to receive the restricted stock award described above, which is subject to the provisions of the Company’s 2009 Stock Incentive Plan (the “Plan”) and the terms and conditions contained in this Restricted Stock Agreement. Please confirm your acceptance of this restricted stock award and of the terms and conditions of this Agreement by signing a copy of this Agreement where indicated below.

LICENSE AND COLLABORATION AGREEMENT by and between ALNYLAM PHARMACEUTICALS, INC. and KYOWA HAKKO KOGYO CO., LTD.
License and Collaboration Agreement • February 18th, 2011 • Alnylam Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

THIS AGREEMENT, effective as of June 19, 2008 (the “Effective Date”), by and between Alnylam Pharmaceuticals, Inc., a corporation organized and existing under the laws of Delaware (“Alnylam”) and Kyowa Hakko Kogyo Co., Ltd., a corporation organized and existing under the laws of Japan (“Kyowa Hakko”).

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. SUBLICENSE AGREEMENT
Sublicense Agreement • February 18th, 2011 • Alnylam Pharmaceuticals, Inc. • Pharmaceutical preparations • British Columbia

ALNYLAM PHARMACEUTICALS, INC., a corporation duly incorporated under the laws of the State of Delaware and having an office at 300 Third Street, 3rd Floor, Cambridge, MA 02142

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. DEVELOPMENT, MANUFACTURING AND SUPPLY AGREEMENT
Development, Manufacturing and Supply Agreement • February 18th, 2011 • Alnylam Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

This Development, Manufacturing and Supply Agreement (the “Agreement”) is entered into as of January 2, 2009 (the “Effective Date”), by and between Alnylam Pharmaceuticals, Inc., a corporation duly incorporated and existing under the laws of the State of Delaware, U.S.A, (“Alnylam”), and Tekmira Pharmaceuticals Corporation, a corporation duly organized and existing under the laws of the Province of British Columbia, Canada (“Tekmira”).

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