0000950123-11-017166 Sample Contracts

Onyx Pharmaceuticals, Inc. 2100 Powell Street Emeryville, California 94608 Tel 510.597.6500 Fax 510.597.6600 www.onyx-pharm.com

Separation and Consulting Agreement • February 23rd, 2011 • Onyx Pharmaceuticals Inc • Biological products, (no disgnostic substances) • California

• Contract Type
  Separation and Consulting Agreement
• Filed
  February 23rd, 2011
• Company
  Onyx Pharmaceuticals Inc
• Industry
  Biological products, (no disgnostic substances)
• Jurisdiction
  California

This Noncompetition And Non-Solicitation Agreement (the “Noncompetition Agreement”) is being executed and delivered as of October 10, 2009, by Michael Kauffman M.D. (“Stockholder”), in favor of, and for the benefit of: Onyx Pharmaceuticals, Inc., a Delaware corporation (“Parent”), and the other Beneficiaries. Certain capitalized terms used in this Noncompetition Agreement are defined in Section 14.

AMENDED AND RESTATED RESEARCH, DEVELOPMENT AND MARKETING COLLABORATION AGREEMENT

Research and Development • February 23rd, 2011 • Onyx Pharmaceuticals Inc • Biological products, (no disgnostic substances) • New York

• Contract Type
  Research and Development
• Filed
  February 23rd, 2011
• Company
  Onyx Pharmaceuticals Inc
• Industry
  Biological products, (no disgnostic substances)
• Jurisdiction
  New York

[*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.