0000950123-11-024354 Sample Contracts

AMENDMENT NO. 5 TO COLLABORATION AND OPTION AGREEMENT
Collaboration and Option Agreement • March 11th, 2011 • Cytokinetics Inc • Pharmaceutical preparations

This Amendment No. 5 to the Agreement (this “Amendment No. 5”) is entered into as of November 1, 2010 (the “Amendment Effective Date”) by and between Cytokinetics, Incorporated (“CK”), a Delaware corporation, having its principal place of business at 280 East Grand Ave., South San Francisco, California 94080 and Amgen Inc., a Delaware corporation having its principal place of business at One Amgen Center Drive, Thousand Oaks, California 91320 (“Amgen”).

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THIRD AMENDMENT TO LEASE
Lease • March 11th, 2011 • Cytokinetics Inc • Pharmaceutical preparations

This THIRD AMENDMENT TO LEASE (“Amendment”) is made and entered into as of the 10th day of December, 2010 (the “Effective Date”), by and between BRITANNIA POINTE GRAND LIMITED PARTNERSHIP, a Delaware limited partnership (“Landlord”), and CYTOKINETICS, INC., a Delaware corporation (“Tenant”).

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