0000950123-14-012668 Sample Contracts

SPARK THERAPEUTICS, INC. RESTRICTED STOCK AGREEMENT GRANTED UNDER 2014 STOCK INCENTIVE PLAN
Restricted Stock Agreement • December 11th, 2014 • Spark Therapeutics, Inc. • Biological products, (no disgnostic substances) • Delaware

This Restricted Stock Agreement (the “Agreement”) is made this [ ] day of [ ], 20[ ], between [Company], a Delaware corporation (the “Company”), and [ ] (the “Participant”).

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LICENSE AGREEMENT between AAVENUE THERAPEUTICS and THE CHILDREN’S HOSPITAL OF PHILADELPHIA®
License Agreement • December 11th, 2014 • Spark Therapeutics, Inc. • Biological products, (no disgnostic substances) • Delaware

This License Agreement (the “Agreement”) is entered into this 14th day of October, 2013 (the “Effective Date”), by and between AAVenue Therapeutics, LLC, a limited liability company organized and existing under the laws of Delaware and having a principal place of business at 34th and Civic Center Blvd, Philadelphia, PA 19104 (“Company”), and The Children’s Hospital of Philadelphia®, a non-profit entity organized and existing under the laws of Pennsylvania and having a principal place of business at 34th and Civic Center Boulevard, Philadelphia, PA 19104 (“CHOP”). Each of Company and CHOP may be referred to as a “Party” and both Company and Licensor may be collectively referred to as the “Parties”.

LICENSE AGREEMENT BY AND BETWEEN PFIZER INC. AND SPARK THERAPEUTICS, INC. Dated as of December 6, 2014
License Agreement • December 11th, 2014 • Spark Therapeutics, Inc. • Biological products, (no disgnostic substances) • New York

This License Agreement (the “Agreement”) is entered into and made effective as of December 6, 2014 (the “Effective Date”), by and between Pfizer Inc., a corporation organized and existing under the laws of the State of Delaware with offices at 235 East 42nd Street, New York, New York 10017 (“Pfizer”) and Spark Therapeutics, Inc. a corporation organized and existing under the laws of the State of Delaware with offices at 3737 Market Street, Suite 1300, Philadelphia, Pennsylvania 19104 (“Spark”). Pfizer and Spark are referred to herein individually as a “Party” and collectively as the “Parties”.

UNIVERSITY Of PENNSYLVANIA Patent License Agreement
Adoption Agreement • December 11th, 2014 • Spark Therapeutics, Inc. • Biological products, (no disgnostic substances) • Pennsylvania

This Patent License Agreement (this “Agreement”) is between The Trustees of the University of Pennsylvania, a Pennsylvania nonprofit corporation (“Penn”), and Spark Therapeutics, Inc., a Delaware corporation (“Company”). This Agreement is being signed on December 2, 2014 (the “Execution Date”). This Agreement will become effective on December 2, 2014(the “Effective Date”).

Common Share Membership Agreement
Common Share Membership Agreement • December 11th, 2014 • Spark Therapeutics, Inc. • Biological products, (no disgnostic substances) • Delaware

This Common Share Membership Agreement (this “Agreement”) is made as of December 16, 2013 (the “Admission Date”), by and between Spark Therapeutics, LLC (the “Company”) and Katherine High, MD (the “Member”).

UNIVERSITY OF PENNSYLVANIA PATENT LICENSE AGREEMENT
Patent License Agreement • December 11th, 2014 • Spark Therapeutics, Inc. • Biological products, (no disgnostic substances) • Pennsylvania

This Patent License Agreement (this “Agreement”) is between The Trustees of the University of Pennsylvania, a Pennsylvania nonprofit corporation (“Penn”), and AAVenue Therapeutics, LLC, a Delaware limited liability company (“Company). This Agreement is being signed on October 14, 2013 (the “Execution Date”). This Agreement will become effective on October 14, 2013 (the “Effective Date”).

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