0000950123-17-008253 Sample Contracts

INDEMNIFICATION AGREEMENT
Indemnification Agreement • August 25th, 2017 • Spero Therapeutics, Inc. • Pharmaceutical preparations • Delaware

THIS INDEMNIFICATION AGREEMENT (the “Agreement”) is made and entered into as of [ ], 201 between SPERO THERAPEUTICS, INC., a Delaware corporation (the “Company”), and [NAME] (“Indemnitee”).

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LEASE AGREEMENT by and between U.S. REIF CENTRAL PLAZA MASSACHUSETTS, LLC as Landlord and SPERO OPCO INC. as Tenant With respect to the property known as 675 Massachusetts Avenue, Cambridge, Massachusetts Dated as of
Lease Agreement • August 25th, 2017 • Spero Therapeutics, Inc. • Pharmaceutical preparations • Massachusetts

THIS LEASE AGREEMENT (the “Lease”) is made and entered into as of this 24th day of August, 2015, by and between U.S. REIF CENTRAL PLAZA MASSACHUSETTS, LLC, a Delaware limited liability company (the “Landlord”), and SPERO OPCO INC., a Delaware corporation (the “Tenant”).

Spero OpCo, Inc. Cambridge, MA 02139
Separation Agreement • August 25th, 2017 • Spero Therapeutics, Inc. • Pharmaceutical preparations

The purpose of this letter agreement (the “Agreement”) is to confirm the terms regarding your separation of employment with Spero OpCo, Inc. (the “Company”) as set forth herein and in that certain employment agreement dated June 24, 2015 (the “Employment Agreement”) between you and the Company. You understand and agree that wherever the term “Company” is used in this Agreement it shall refer to Company, its divisions, parent, affiliates, subsidiaries and related entities, and its and their respective officers, directors, employees, agents, representatives, successors and assigns. As more fully set forth below, Company desires to provide you with severance pay as outlined in the Employment Agreement in exchange for certain agreements by you.

RESTRICTED STOCK AGREEMENT SPERO THERAPEUTICS, INC.
Restricted Stock Agreement • August 25th, 2017 • Spero Therapeutics, Inc. • Pharmaceutical preparations • Delaware

AGREEMENT made as of the [ ] day of [ ], 2017 (the “Grant Date”), between Spero Therapeutics, Inc. (the “Company”), a Delaware corporation, and [ ] (the “Participant”).

SPERO THERAPEUTICS, INC. INVESTORS’ RIGHTS AGREEMENT JUNE 30, 2017
Investors’ Rights Agreement • August 25th, 2017 • Spero Therapeutics, Inc. • Pharmaceutical preparations • Delaware

THIS INVESTORS’ RIGHTS AGREEMENT (this “Agreement”) is made as of the 30th day of June, 2017, by and among Spero Therapeutics, Inc., a Delaware corporation (the “Company”), and each of the investors listed on Schedule A hereto, each of which is referred to in this Agreement as an “Investor”, and each of the stockholders listed on Schedule B hereto, each of whom is referred to herein as a “Key Holder.”

SUBLEASE
Sublease • August 25th, 2017 • Spero Therapeutics, Inc. • Pharmaceutical preparations • Massachusetts

This SUBLEASE (“Sublease”) is made as of July 6, 2016 (the “Effective Date”), by and between Tetraphase Pharmaceuticals, Inc., a Delaware corporation having a place of business at 480 Arsenal Street, Watertown, MA 02472 (“Sublessor”) and SperoOpCo, Inc., a Delaware corporation (“Sublessee”).

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