0000950123-18-001270 Sample Contracts

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. ASSET PURCHASE AGREEMENT by and between
Asset Purchase Agreement • February 9th, 2018 • Translate Bio, Inc. • Biological products, (no disgnostic substances) • Delaware

THIS ASSET PURCHASE AGREEMENT (this “Agreement”) is entered into as of December 22, 2016, by and between RaNA Therapeutics, Inc., a Delaware corporation (the “Buyer”), and Shire Human Genetic Therapies, Inc., a Delaware corporation (the “Seller”).

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LEASE AGREEMENT
Lease Agreement • February 9th, 2018 • Translate Bio, Inc. • Biological products, (no disgnostic substances)

THIS LEASE AGREEMENT (this “Lease”) is made this 29 day of June, 2017, between ARE-MA REGION NO. 8, LLC, a Delaware limited liability company (“Landlord”), and RANA DEVELOPMENT, INC., a Delaware corporation (“Tenant”).

Re: Employment Agreement
General Release Agreement • February 9th, 2018 • Translate Bio, Inc. • Biological products, (no disgnostic substances) • Massachusetts

On behalf of RaNA Therapeutics, LLC (“RaNA” or the “Company”), I am pleased to offer you the position of the Company’s Chief Scientific Officer (“CSO”). The key provisions of this offer is contingent upon full Board approval. Please note this offer is also contingent upon the successful completion of references and routine background checks and work authorization.

October 31, 2014 BY EMAIL Mr. Ronald Renaud Re: Employment Agreement Dear Ron:
General Release Agreement • February 9th, 2018 • Translate Bio, Inc. • Biological products, (no disgnostic substances) • Massachusetts

On behalf of RaNA Therapeutics, LLC (“RaNA” or the “Company”), I am pleased to offer you the position of the Company’s Chief Executive Officer (“CEO”). The terms of your employment are set forth below.

TRANSLATE BIO, INC. INCENTIVE STOCK OPTION AGREEMENT GRANTED UNDER 2016 STOCK INCENTIVE PLAN
Incentive Stock Option Agreement • February 9th, 2018 • Translate Bio, Inc. • Biological products, (no disgnostic substances)
RANA THERAPEUTICS, INC. AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT DECEMBER 22, 2016
Registration Rights Agreement • February 9th, 2018 • Translate Bio, Inc. • Biological products, (no disgnostic substances) • Delaware

THIS AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made as of the 22nd day of December, 2016, by and among RaNA Therapeutics, Inc., a Delaware corporation (the “Company”), and each of the investors listed on Schedule A hereto, each of which is referred to in this Agreement as an “Investor”.

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