0000950129-05-004666 Sample Contracts

AMENDMENT NO. 3 TO AMENDED AND RESTATED PROMOTION AGREEMENT
Promotion Agreement • May 4th, 2005 • Amgen Inc • Biological products, (no disgnostic substances)

This Amendment No. 3 (this “Amendment”), entered into as of this 19th day of April, 2005 and effective as of the 1st day of January, 2005 (the “Effective Date”), is made by and among Wyeth, a Delaware corporation (formerly American Home Products Corporation, “Wyeth”), Amgen Inc., a Delaware corporation (“Amgen”), and Immunex Corporation, a Washington corporation and wholly-owned subsidiary of Amgen (“Immunex”) and amends the Amended and Restated Promotion Agreement dated as of December 16, 2001 which became effective on July 15, 2002, as amended by Amendment No. 1 to Collaboration and Global Supply Agreement, Amended and Restated Promotion Agreement, and TNFR License and Development Agreement effective as of July 8, 2003 among Wyeth, Amgen and Immunex and by Amendment No. 2 to Collaboration and Global Supply Agreement and Amended and Restated Promotion Agreement effective as of April 20, 2004 among Wyeth, Amgen and Immunex (as amended, the “Promotion Agreement”).

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