EXHIBIT 4.2 SECURITIES PURCHASE AGREEMENT This SECURITIES PURCHASE AGREEMENT (the "AGREEMENT"), dated as of December 14, 2001, is entered into by and among EntreMed, Inc., a Delaware corporation, with headquarters located at 9640 Medical Center Drive,...Securities Purchase Agreement • January 16th, 2002 • Entremed Inc • Biological products, (no disgnostic substances) • New York
EXHIBIT 4.3 REGISTRATION RIGHTS AGREEMENT This REGISTRATION RIGHTS AGREEMENT (this "AGREEMENT"), dated as of December 14, 2001, is entered into by and among EntreMed, Inc., a Delaware corporation, with headquarters located at 9640 Medical Center...Registration Rights Agreement • January 16th, 2002 • Entremed Inc • Biological products, (no disgnostic substances) • New York
