0000950133-03-000114 Sample Contracts

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • January 15th, 2003 • Entremed Inc • Biological products, (no disgnostic substances) • New York

This Securities Purchase Agreement (this “Agreement”) is made and effective as of December 31, 2002 by and among EntreMed, Inc., a Delaware corporation (the “Company”), and Celgene Corporation, a Delaware corporation (the “Purchaser”).

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ASSET PURCHASE AGREEMENT by and between Celgene Corporation as Purchaser and EntreMed, Inc. as Seller Dated as of December 31, 2002
Asset Purchase Agreement • January 15th, 2003 • Entremed Inc • Biological products, (no disgnostic substances) • New York

THIS ASSET PURCHASE AGREEMENT (this “Agreement”) is made as of the 31st day of December, 2002, by and between Celgene Corporation, a Delaware corporation (“Purchaser”), and EntreMed, Inc., a Delaware corporation (“Seller”).

INVESTOR AND REGISTRATION RIGHTS AGREEMENT
Investor and Registration Rights Agreement • January 15th, 2003 • Entremed Inc • Biological products, (no disgnostic substances) • New York

This INVESTOR AND REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made and effective as of December 31, 2002 by and between EntreMed, Inc., a Delaware corporation (the “Company”), and Celgene Corporation, a Delaware corporation (the “Holder”).

CELGENE CORPORATION 7 Powder Horn Drive Warren, New Jersey 07059
Entremed Inc • January 15th, 2003 • Biological products, (no disgnostic substances)

Reference is made to the Asset Purchase Agreement dated as of the date hereof between Celgene Corporation (“Celgene”) and EntreMed, Inc. (“EntreMed”).

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