0000950133-05-005135 Sample Contracts

AMENDMENT TO THE INVESTOR RIGHTS AGREEMENT
Rights Agreement • November 14th, 2005 • Iomai Corp • Pharmaceutical preparations

This Amendment (this “Amendment”) to that certain Investor Rights Agreement dated as of December 4, 2002 (the “Rights Agreement”) by and among Iomai Corporation, a Delaware corporation (the “Company”), and the Purchasers party thereto is entered into as of March 27, 2003 by and among the Company and those Purchasers listed on the signature pages hereto (the “Consenting Purchasers”). The Company and the Consenting Purchasers collectively are referred to herein as the “Parties.” Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Rights Agreement.

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AMENDMENT TO INVESTOR RIGHTS AGREEMENT AND CONSENT
Investor Rights Agreement and Consent • November 14th, 2005 • Iomai Corp • Pharmaceutical preparations

This Amendment to Investor Rights Agreement and Consent (this “Amendment and Consent”) is entered into as of this 30th day of May 2003 by and among Iomai Corporation, a Delaware corporation (the “Company”), and those Purchasers listed on the signature pages hereto (the “Consenting Purchasers”). The Company and the Consenting Purchasers collectively are referred to herein as the “Parties.” Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in that certain Investor Rights Agreement by and among the Company and the Purchasers (as defined therein) party thereto, dated December 4, 2002, as amended (the “Investor Rights Agreement”).

FOURTH AMENDMENT TO LEASE
Lease • November 14th, 2005 • Iomai Corp • Pharmaceutical preparations

This Fourth Amendment (the “Fourth Amendment”) to Lease is made as of October 26, 2005, by and between ARE-20/22/1300 FIRSTFIELD QUINCE ORCHARD, LLC, a Delaware limited liability company (“Landlord”), and IOMAI CORPORATION, a Delaware corporation (“Tenant”).

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