0000950133-06-003016 Sample Contracts

INDEMNIFICATION AGREEMENT
Indemnification Agreement • June 19th, 2006 • Sucampo Pharmaceuticals, Inc. • Delaware

INDEMNIFICATION AGREEMENT (this “Agreement”) dated as of May 26, 2004 by and between Sucampo Pharmaceuticals, Inc. (the “Company”), a Delaware corporation, and Hidetoshi Mine (“Indemnitee”):

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EMPLOYMENT AGREEMENT
Employment Agreement • June 19th, 2006 • Sucampo Pharmaceuticals, Inc.

THIS EMPLOYMENT AGREEMENT (the “Agreement”), dated as of , 2006 (the “Effective Date”), is hereby entered into in the State of Maryland by and between SUCAMPO PHARMACEUTICALS, INC., a Delaware corporation (the “Company”), and (“Executive”).

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • June 19th, 2006 • Sucampo Pharmaceuticals, Inc. • New York

THIS COLLABORATION AND LICENSE AGREEMENT (the “Agreement”) is made as of October 29, 2004, by and between Sucampo Pharmaceuticals, Inc., a corporation organized under the laws of Delaware, having its principal place of business at 4733 Bethesda Avenue, Suite 450, Bethesda, Maryland 20814 USA (“SPI”), and Takeda Pharmaceutical Company Limited, a corporation organized under the laws of Japan, having its principal place of business at 1-1 Doshomachi 4-chome, Chuo-ku, Osaka 540-8645, Japan (“Takeda”). SPI and Takeda are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

SUPPLY AND PURCHASE AGREEMENT
Supply and Purchase Agreement • June 19th, 2006 • Sucampo Pharmaceuticals, Inc. • New York

THIS SUPPLY AND PURCHASE AGREEMENT is made as of January 25, 2006, by and among Sucampo Pharmaceuticals, Inc., a Delaware corporation having its principal place of business at 4733 Bethesda Avenue, Suite 450, Bethesda, Maryland 20814 USA (“SPI”), Takeda Pharmaceutical Company Limited, a corporation organized under the laws of Japan having its principal place of business at 1-1, Doshomachi 4-chome, Chuo-ku, Osaka 540-8645, JAPAN (“Takeda”) and R-Tech Ueno, Ltd., a corporation organized under the laws of Japan having its principal place of business at 10F, Yamato Life Insurance Bldg., 1-1-7 Uchisaiwaicho, Chiyoda-ku, Tokyo 100-0011, JAPAN (“RTU”) (this “Agreement”). SPI, Takeda and RTU are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. SUPPLY AGREEMENT
Supply Agreement • June 19th, 2006 • Sucampo Pharmaceuticals, Inc. • New York

THIS SUPPLY AGREEMENT is made as of October 29, 2004, by and among Sucampo Pharmaceuticals, Inc., a Delaware corporation having its principal place of business at 4733 Bethesda Avenue, Suite 450, Bethesda, Maryland 20814 USA (“SPI”), Takeda Pharmaceutical Company Limited, a corporation organized under the laws of Japan having its principal place of business at 1-1, Doshomachi 4-chome, Chuo-ku, Osaka 540-8645, JAPAN (“Takeda”) and R-Tech Ueno, Ltd., a corporation organized under the laws of Japan having its principal place of business at 10F, Yamato Life Insurance Bldg., 1-1-7 Uchisaiwaicho, Chiyoda-ku, Tokyo 100-0011, JAPAN (“RTU”) (this “Agreement”). SPI, Takeda and RTU are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

SUBLEASE AGREEMENT
Sublease Agreement • June 19th, 2006 • Sucampo Pharmaceuticals, Inc. • Maryland

THIS SUBLEASE AGREEMENT (“Sublease”) is made this 26th day of October, 2005, by and between First Potomac Realty Investment L.P., a Delaware limited partnership (“Sublessor”) and Sucampo Pharmaceuticals, Inc., a Delaware corporation (“Sublessee”).

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. SUPPLEMENTAL AGREEMENT
Supplemental Agreement • June 19th, 2006 • Sucampo Pharmaceuticals, Inc. • New York

THIS SUPPLEMENTAL AGREEMENT (the “Supplemental Agreement”) is made as of February 1, 2006, by and between Sucampo Pharmaceuticals, Inc., a corporation organized under the laws of Delaware, having its principal place of business at 4733 Bethesda Avenue, Suite 450, Bethesda, Maryland 20814 USA (“SPI”), and Takeda Pharmaceutical Company Limited, a corporation organized under the laws of Japan, having its principal place of business at 1-1 Doshomachi 4-chome, Chuo-ku, Osaka 540-8645, Japan (“Takeda”). SPI and Takeda are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

INDEMNIFICATION AGREEMENT
Indemnification Agreement • June 19th, 2006 • Sucampo Pharmaceuticals, Inc. • Delaware

INDEMNIFICATION AGREEMENT (this “Agreement”) dated as of May 23, 2006 by and between Sucampo Pharmaceuticals, Inc. (the “Company”), a Delaware corporation, and Gregory D. Perry (“Indemnitee”):

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. AGREEMENT
Agreement • June 19th, 2006 • Sucampo Pharmaceuticals, Inc. • New York

THIS AGREEMENT is made as of October 29, 2004, by and among Sucampo Pharmaceuticals, Inc., a Delaware corporation having its principal place of business at 4733 Bethesda Avenue, Suite 450, Bethesda, Maryland 20814 USA (“SPI”), Takeda Pharmaceutical Company Limited, a corporation organized under the laws of Japan having its principal place of business at 1-1, Doshomachi 4-chome, Chuo-ku, Osaka 540-8645, JAPAN (“Takeda”) and Sucampo AG, a corporation organized under the laws of Switzerland and having its principal office at Graben 5, CH-6300 Zug, Switzerland (“SAG”) (this “Agreement”). SPI, Takeda and SAG are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

ARTICLE PAGE 1. DEFINITIONS 1 2. TERM 4 3. WORK AGREEMENT 4 4. RENT 5 5. ADDITIONAL RENT 6 6. USE 8 7. CARE OF PREMISES 8 8. ALTERATIONS BY TENANT 8 9. EQUIPMENT 9 10. OWNERSHIP AND REMOVAL OF PROPERTY 10 11. LANDLORD’S ACCESS TO PREMISES 11 12....
Office Lease • June 19th, 2006 • Sucampo Pharmaceuticals, Inc. • Maryland

THIS LEASE (the “Lease”) is made and entered into this 16th day of September, 1998, by and between TRIZECHAHN PLAZA WEST LIMITED PARTNERSHIP, a Maryland limited partnership (“Landlord”) and R-TECH UENO (USA), INC., a Delaware corporation (“Tenant”).

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