0000950133-07-001749 Sample Contracts

April 9, 2007 Mr. Dane Saglio Chief Financial Officer EntreMed, Inc. 9640 Medical Center Drive Rockville, MD 20850 Dear Dane,
Entremed Inc • April 17th, 2007 • Biological products, (no disgnostic substances)

The Compensation Committee has approved a one-year extension of your Employment Agreement (the “Agreement”) for the period commencing July 1, 2007 through June 30, 2008.

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CHANGE IN CONTROL AGREEMENT
Change in Control Agreement • April 17th, 2007 • Entremed Inc • Biological products, (no disgnostic substances) • Maryland

WHEREAS the Company considers it essential to its best interests and to the best interests of its stockholders to foster the continuous employment of its key management personnel; and

ENTREMED LETTERHEAD]
Entremed Inc • April 17th, 2007 • Biological products, (no disgnostic substances)

This letter is to confirm the proposed amendment to the terms of your employment agreement, effective as of May 20, 2005 (the “Agreement”). The Compensation Committee approved this amendment on March 9, 2007. Capitalized terms used in this letter without definition have the meanings set forth in the Agreement.

ENTREMED LETTERHEAD]
Entremed Inc • April 17th, 2007 • Biological products, (no disgnostic substances)

This letter is to confirm the proposed amendment to the terms of your employment agreement, effective as of December 1, 2004 (the “Agreement”). The Compensation Committee approved this amendment on March 9, 2007. Capitalized terms used in this letter without definition have the meanings set forth in the Agreement.

ENTREMED LETTERHEAD]
Entremed Inc • April 17th, 2007 • Biological products, (no disgnostic substances)

This letter is to confirm the proposed amendment to the terms of your employment agreement, effective as of June 1, 2006 (the “Agreement”). The Compensation Committee approved this amendment on March 9, 2007. Capitalized terms used in this letter without definition have the meanings set forth in the Agreement.

EntreMed, Inc. 2001 Long-Term Incentive Plan Non-Qualified Stock Option Grant Agreement
Option Grant Agreement • April 17th, 2007 • Entremed Inc • Biological products, (no disgnostic substances) • Maryland
EntreMed, Inc. 2001 Long-Term Incentive Plan Non-Qualified Stock Option Grant Agreement
Option Grant Agreement • April 17th, 2007 • Entremed Inc • Biological products, (no disgnostic substances) • Maryland
ENTREMED LETTERHEAD]
Entremed Inc • April 17th, 2007 • Biological products, (no disgnostic substances)

This letter is to confirm the proposed amendment to the terms of your employment agreement, effective as of June 15, 2004 (the “Agreement”). The Compensation Committee approved this amendment on March 9, 2007. Capitalized terms used in this letter without definition have the meanings set forth in the Agreement.

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