0000950133-07-004471 Sample Contracts

WARRANT TO PURCHASE 125,000 SHARES OF COMMON STOCK
Entremed Inc • November 8th, 2007 • Biological products, (no disgnostic substances) • New York

THIS CERTIFIES THAT, for value received, General Electric Capital Corporation (“Holder”) is entitled to subscribe for and purchase One Hundred Twenty-Five Thousand (125,000) shares of fully paid and nonassessable Common Stock of EntreMed, Inc., a Delaware corporation (“Company”), at the Warrant Price (as hereinafter defined), subject to the provisions and upon the terms and conditions hereinafter set forth. As used herein, the term “Common Stock” shall mean Company’s presently authorized common stock, $0.01 par value per share, and any stock into which such common stock may hereafter be converted or exchanged and the term “Warrant Shares” shall mean the shares of Common Stock which Holder may acquire pursuant to this Warrant and any other shares of stock into which such shares of Common Stock may hereafter be converted or exchanged.

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LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • November 8th, 2007 • Entremed Inc • Biological products, (no disgnostic substances)

THIS LOAN AND SECURITY AGREEMENT, dated as of September 12, 2007 (as amended, restated, supplemented or otherwise modified from time to time (this “Agreement”)) is among GENERAL ELECTRIC CAPITAL CORPORATION (“GECC”), in its capacity as agent for Lenders (as defined below), together with its successors and assigns in such capacity, “Agent”), the financial institutions who are or hereafter become parties to this Agreement as lenders (together with GECC, collectively the “Lenders”, and each individually, a “Lender”), ENTREMED, INC., a Delaware corporation (“Borrower”) and MIIKANA THERAPEUTICS, INC., a Delaware corporation (“Miikana” and together with Borrower, each a “Loan Party” and collectively the “Loan Parties”). Agent has an office at 83 Wooster Heights Road, Fifth Floor, Danbury, CT 06810 (the “Agent’s Office”). Borrower’s mailing address and chief executive office is 9640 Medical Center Drive, Rockville, MD 20850.

WARRANT TO PURCHASE 62,500 SHARES OF COMMON STOCK
Entremed Inc • November 8th, 2007 • Biological products, (no disgnostic substances) • New York

THIS CERTIFIES THAT, for value received, Oxford Finance Corporation (“Holder”) is entitled to subscribe for and purchase Sixty-Two Thousand Five Hundred (62,500) shares of fully paid and nonassessable Common Stock of EntreMed, Inc., a Delaware corporation (“Company”), at the Warrant Price (as hereinafter defined), subject to the provisions and upon the terms and conditions hereinafter set forth. As used herein, the term “Common Stock” shall mean Company’s presently authorized common stock, $0.01 par value per share, and any stock into which such common stock may hereafter be converted or exchanged and the term “Warrant Shares” shall mean the shares of Common Stock which Holder may acquire pursuant to this Warrant and any other shares of stock into which such shares of Common Stock may hereafter be converted or exchanged.

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