0000950134-06-013701 Sample Contracts

FIRST SUPPLEMENTAL INDENTURE
First Supplemental Indenture • July 24th, 2006 • Connetics Corp • Pharmaceutical preparations • New York

FIRST SUPPLEMENTAL INDENTURE, dated as of July 21, 2006, among Connetics Corporation, a Delaware corporation (the “Company”) and J.P. Morgan Trust Company, National Association, as trustee (the “Trustee”).

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