0000950134-06-019550 Sample Contracts

AGREEMENT AND PLAN OF MERGER
Merger Agreement • October 24th, 2006 • Connetics Corp • Pharmaceutical preparations • Delaware
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October 22, 2006 Computershare Trust Company, N.A. 150 Royall Street Canton, MA 02021 Re: Amendment No. 1 to Rights Agreement Ladies and Gentlemen:
Rights Agreement • October 24th, 2006 • Connetics Corp • Pharmaceutical preparations • Delaware

Pursuant to Section 27 of the Amended and Restated Preferred Stock Rights Agreement, dated as of November 21, 2001 (the “Rights Agreement”), between Connetics Corporation, a Delaware corporation (the “Company”) and Computershare Trust Company, N.A., as Rights Agent (the “Rights Agent”), the Company, by resolution adopted by its Board of Directors, hereby amends the Rights Agreement as follows:

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