0000950134-08-001011 Sample Contracts

OREXIGEN THERAPEUTICS, INC. (a Delaware corporation) 7,000,000 Shares of Common Stock PURCHASE AGREEMENT
Purchase Agreement • January 24th, 2008 • Orexigen Therapeutics, Inc. • Pharmaceutical preparations • New York

MERRILL LYNCH & CO. Merrill Lynch, Pierce, Fenner & Smith Incorporated as Representative of the several Underwriters 4 World Financial Center New York, New York 10080

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