December 1, 2008 VIA HAND DELIVERY Mr. Henry Fuchs Onyx Pharmaceuticals, Inc. 2100 Powell Street Emeryville, CA 94608 Re: Separation Agreement Dear Hank:Separation Agreement • December 1st, 2008 • Onyx Pharmaceuticals Inc • Biological products, (no disgnostic substances) • California
Contract Type FiledDecember 1st, 2008 Company Industry JurisdictionThis letter sets forth the terms of the separation agreement (the “Agreement”) that Onyx Pharmaceuticals, Inc. (the “Company”) is offering to you to facilitate your separation from the Company: