0000950135-07-006859 Sample Contracts

AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • November 9th, 2007 • Critical Therapeutics Inc • Pharmaceutical preparations • Massachusetts

THIS AMENDED AND RESTATED EMPLOYMENT AGREEMENT (the “Agreement”), is entered into as of November 6, 2007 (the “Effective Date”) by and between Critical Therapeutics, Inc., a Delaware corporation with its principal place of business at 60 Westview Street, Lexington, MA 02421 (the “Company”), and Scott B. Townsend, an individual residing at 36 Ridge Hill Road, Sudbury, MA 01776 (the “Executive”).

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MANUFACTURING AND SUPPLY AGREEMENT
Manufacturing and Supply Agreement • November 9th, 2007 • Critical Therapeutics Inc • Pharmaceutical preparations • England

This MANUFACTURING & SUPPLY AGREEMENT (this “Agreement”), dated as of August 20, 2007 by and among (i) Critical Therapeutics, Inc. , a Delaware corporation having a place of business at 60 Westview Street, Lexington, MA 02421, USA (“CRTX”), (ii) Jagotec AG, a Swiss company having a place of business at Eptingerstrasse 51, CH-4132 Muttenz, Switzerland (“Jagotec”) and (iii) for the purposes of clause 20 only, SkyePharma PLC, an English company having a place of business at 105 Piccadilly, London W1J 7NJ (Jagotec and CRTX individually referred to as a “Party” and together as the “Parties”).

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. FIRST AMENDMENT TO MANUFACTURING SERVICES AGREEMENT
Manufacturing Services Agreement • November 9th, 2007 • Critical Therapeutics Inc • Pharmaceutical preparations

This First Amendment to the Manufacturing Services Agreement (the “First Amendment”) between Patheon Pharmaceuticals Inc., (“Patheon”) and Critical Therapeutics, Inc., (“Client”) shall be effective November 5, 2007 (the “Effective Date:”).

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