0000950135-09-003718 Sample Contracts

CONTINGENT VALUE RIGHTS AGREEMENT
Contingent Value Rights Agreement • May 7th, 2009 • EPIX Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

CONTINGENT VALUE RIGHTS AGREEMENT (this “Agreement”) dated as of May 7, 2009, by and among EPIX Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and U.S. Bank National Association, a national banking association organized under the laws of the United States, as Rights Agent (the “Rights Agent”), in favor of each person (a “Holder”) who from time to time holds one or more contingent value rights (the “CVRs”) to receive contingent payments, in the amounts and subject to the terms and conditions set forth herein.

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SECOND SUPPLEMENTAL INDENTURE
Second Supplemental Indenture • May 7th, 2009 • EPIX Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

THIS SECOND SUPPLEMENTAL INDENTURE, dated as of May 7, 2009 (this “Second Supplemental Indenture”), to the Indenture (as defined below), is hereby entered into by and between EPIX Pharmaceuticals, Inc. (f/k/a EPIX Medical, Inc.), a Delaware corporation (the “Issuer”) and U.S. Bank National Association, a national banking association organized under the laws of the United States, as Trustee (the “Trustee”).

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