0000950144-06-011820 Sample Contracts

SECOND AMENDMENT TO INVESTORS’ RIGHTS AGREEMENT
Investors’ Rights Agreement • December 22nd, 2006 • Sirion Holdings, Inc. • Blank checks

This Second Amendment to Investors’ Rights Agreement (this “Second Amendment”) is made and entered into as of December 20, 2006, among SIRION HOLDINGS, INC. (f/k/a Tenby Pharma Inc.), a Delaware corporation (the “Company”), and the investors signatory hereto (each such investor is a “Investor” and all such investors are, collectively, the “Investors”). All capitalized terms set forth in this Second Amendment but not otherwise defined herein shall have the meaning ascribed thereto in the Original Agreement.

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