0000950149-08-000077 Sample Contracts

June 23, 2008 VIA HAND DELIVERY Mr. Gregory Schafer Onyx Pharmaceuticals, Inc. 2100 Powell Street Emeryville, CA 94608 Re: Separation and Consulting Agreement Dear Greg:
Separation and Consulting Agreement • June 23rd, 2008 • Onyx Pharmaceuticals Inc • Biological products, (no disgnostic substances) • California

This letter sets forth the terms of the separation agreement (the “Agreement”) that Onyx Pharmaceuticals, Inc. (the “Company”) is offering to you to facilitate your separation from the Company:

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