0000950162-01-500922 Sample Contracts

ISSUER
Indenture • November 6th, 2001 • Shire Pharmaceuticals Group PLC • Pharmaceutical preparations • New York
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Guaranteed by
Shire Pharmaceuticals Group PLC • November 6th, 2001 • Pharmaceutical preparations • New York
GUARANTOR
Preference Shares Guarantee Agreement • November 6th, 2001 • Shire Pharmaceuticals Group PLC • Pharmaceutical preparations • New York
Guaranteed by
Shire Pharmaceuticals Group PLC • November 6th, 2001 • Pharmaceutical preparations • New York
August 17, 2001 Dear Mr. Brecher: Re: Purchase Agreement by Shire Finance Limited dated as of August 15, 2001 guaranteed by Shire Pharmaceuticals Group plc, Indenture among Shire Finance Limited (the "Issuer:), Shire Pharmaceuticals Group plc (the...
Shire Pharmaceuticals Group PLC • November 6th, 2001 • Pharmaceutical preparations

Re: Purchase Agreement by Shire Finance Limited dated as of August 15, 2001 guaranteed by Shire Pharmaceuticals Group plc, Indenture among Shire Finance Limited (the "Issuer:), Shire Pharmaceuticals Group plc (the "Guarantor") to the Bank of New York ("Trustee") dated as of August 21, 2001 and the Preference Shares Guarantee Agreement by Shire Finance Limited, Shire Pharmaceuticals Group plc (the "Guarantor") and The Bank of New York ("Guarantee Trustee") dated July __, 2001 in respect of the 2% Senior Guaranteed Convertible Notes Due 2011.

GUARANTEE
Shire Pharmaceuticals Group PLC • November 6th, 2001 • Pharmaceutical preparations

For value received, SHIRE PHARMACEUTICALS GROUP PLC, a public limited company organized and existing under the laws of England and Wales (herein called the "Guarantor", which term includes any successor Person under the Indenture referred to in the Security upon which this Guarantee is endorsed), hereby irrevocably and unconditionally guarantees to the Holder of the Security upon which this Guarantee is endorsed, and to the Trustee on behalf of each such Holder, the due and punctual payment of the principal of (and premium, if any, on) and interest, if any, on such Security when and as the same shall become due and payable, whether at the Stated Maturity, by declaration of acceleration, call for redemption or otherwise, in accordance with the terms of said Security and of the Indenture. In case of the failure of the Issuer punctually to make any such payment of principal (or premium, if any) or interest, if any, the Guarantor hereby agrees to cause any such payment to be made punctuall

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