0000950170-22-002548 Sample Contracts

KARYOPHARM THERAPEUTICS INC. Restricted Stock Unit Agreement (Time Vested) 2013 Stock Incentive Plan NOTICE OF GRANT
Restricted Stock Unit Agreement • March 1st, 2022 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations • Delaware

This Restricted Stock Unit Agreement (this “Agreement”) is made as of the Agreement Date between Karyopharm Therapeutics Inc. (the “Company”), a Delaware corporation, and the Participant.

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KARYOPHARM THERAPEUTICS INC. Nonstatutory STOCK OPTION AGREEMENT Granted Under 2022 Inducement Stock Incentive Plan
Nonstatutory Stock Option Agreement • March 1st, 2022 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations

This option satisfies in full all commitments that the Company has to the Participant with respect to the issuance of stock, stock options or other equity securities.

LICENSE AGREEMENT between KARYOPHARM THERAPEUTICS INC. and
License Agreement • March 1st, 2022 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations

This LICENSE AGREEMENT (“Agreement”) is effective as of this 17th day of December, 2021 (“Effective Date”), between KARYOPHARM THERAPEUTICS INC., a corporation organized and existing under the law of Delaware and having its principal place of business at 85 Wells Ave., 2nd floor Newton, MA 02459 (“LICENSOR”) and BERLIN-CHEMIE AG, a corporation organized and existing under the law of Germany and having its principal place of business at Glienicker Weg 125, 12489 Berlin, Germany (“LICENSEE”).

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