0000950170-23-005062 Sample Contracts

November 18, 2022 Mr. Douglas S. Ingram Re: Amendments to Employment Agreement Dear Doug:
Employment Agreement • February 28th, 2023 • Sarepta Therapeutics, Inc. • Pharmaceutical preparations

This letter agreement (“Letter Agreement”) amends, effective on the date above, certain terms of the Employment Agreement (the “Employment Agreement”) dated June 26, 2017 between you and Sarepta Therapeutics, Inc. (the “Company”). This Letter Agreement is intended to relate to the Letter Agreement dated April 19, 2022 between you and the Company. Except as provided herein, the Employment Agreement will continue in accordance with its terms.

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SEPARATION AND CONSULTING AGREEMENT AND GENERAL RELEASE
Separation and Consulting Agreement • February 28th, 2023 • Sarepta Therapeutics, Inc. • Pharmaceutical preparations • Massachusetts

This Separation and Consulting Agreement and General Release (the “Agreement”) by and between Bill Ciambrone (“Employee”) and Sarepta Therapeutics, Inc. (the “Company”), is made effective as of the date following Employee’s signature and the expiration of the seven (7) day revocation period without revocation (the “Effective Date”) with reference to the following facts:

TENTH AMENDMENT TO LICENSE, COLLABORATION, AND OPTION AGREEMENT
License, Collaboration, and Option Agreement • February 28th, 2023 • Sarepta Therapeutics, Inc. • Pharmaceutical preparations • New York

WHEREAS, Sarepta and Roche entered into that certain License, Collaboration, and Option Agreement executed on December 21, 2019 and effective as of February 4, 2020 and amended October 23, 2020,

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